Vitamin D and Age-Related Macular Degeneration
نویسندگان
چکیده
In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
منابع مشابه
Vitamin E supplementation and macular degeneration: randomised controlled trial.
OBJECTIVE To determine whether vitamin E supplementation influences the incidence or rate of progression of age related maculopathy (AMD). DESIGN Prospective randomised placebo controlled clinical trial. SETTING An urban study centre in a residential area supervised by university research staff. PARTICIPANTS 1193 healthy volunteers aged between 55 and 80 years; 73% completed the trial on ...
متن کاملTranspupilary thermotherapy of occult subfoveal choroidal neovascularization secondary to age related macular degeneration
Abstract Background: Transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. This study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. Methods: In a ...
متن کاملهمراهی پلیمورفیسم p.Gly119Arg ژن CFI در مبتلایان به بیماری دژنراسیون ماکولای وابسته به سن در جمعیت ساکن در شهر تهران
Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and is characterized by progressive degeneration of the retinal pigment epithelium and secondary photoreceptor loss, resulting in visual loss. Etiological research suggests that age related macular degeneration is a complex disease, caused by the interactions of several genetic and enviro...
متن کاملمروری بر روش های کمک بینایی به منظور بهبود کیفیت زندگی بیماران مبتلا به دژنراسیون وابسته به سن ماکولا
Background and purpose: Age related macular degeneration is the most common cause of sever visual impairment and blindness among adults over the age of 65 years in developed countries. The purpose of this study was to review the literature on using low vision aids in age related macular degeneration and their effects on their quality of life. Materials and methods: A comprehensive search of ...
متن کاملVitamin D and macular thickness in the elderly: an optical coherence tomography study.
PURPOSE Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. METHODS Sixty-two French older community-dwellers with no patent macular dysfunction (mean ± SD, 71.2 ± 5.0 years; 45.2% fem...
متن کامل