Vitamin D and Age-Related Macular Degeneration

نویسندگان

  • Alfredo Garcia Layana
  • Angelo Maria Minnella
  • Gerhard Garhöfer
  • Tariq Aslam
  • Frank G Holz
  • Anita Leys
  • Rufino Silva
  • Cécile Delcourt
  • Eric Souied
  • Johanna M Seddon
چکیده

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

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عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2017